What is the endocannabinoid system?

endocannabinoid system

When you take CBD oil, you can feel its anti-inflammatory benefits as it eases pain and gives you a good night sleep. The reason behind your body’s positive response to CBD oil is the endocannabinoid system. Let’s learn more about the endocannabinoid system and how CBD oil can help you get your life back.

Every human has an endocannabinoid system, and many animals too. The role of your endocannabinoid system is to maintain balance (homeostasis) in your brain and body. Your endocannabinoid system plays an important role in modulating how you respond to stress and anxiety, as well as appetite, sleep and cognition.

What are Endocannabinoids?

Your endocannabinoid system is made up of three main parts:

  • Cannabinoid receptors. Found on the surface of cells, your cannabinoid receptors (CB1 & CB2) are found throughout your body. They perform a wide variety of functions and help your body maintain balance.
  • Endocannabinoids. These are cannabinoids produced in your body that act as chemical messengers that bind to your cannabinoid receptors, activating them in your body. When your body doesn’t produce enough endocannabinoids, it can use phytocannabinoids derived from hemp.
  • Enzymes. These break down leftover endocannabinoids.

Endocannabinoid System Discovery—Who Discovered the Endocannabinoid System?

The endocannabiniod system was discovered by Israeli researcher Dr. Ralph Mechoulam in the mid-1990’s. An organic chemist, Dr. Mechoulam was among the first to complete the total synthesis of the cannabinoids THC (tetrahydracannabidiol), CBD (cannabidiol) and CBG (cannabigerol). He also played a role in isolating and describing an important endocannabinoid called anandamide (3).

Cannabinoid Receptors in the Human Body—Where are They Located? What Do They Do?

Your body has two main cannabinoid receptors: cannabidiol 1 (CB1) & cannabidiol 2 (CB2). CB1 receptors are primarily found in the brain, although they are also found in male and female reproductive organs. CB2 receptors are primarily found in the immune system, with the highest concentration in the womb. Your cannabinoid receptors configured to accept only cannabinoids like CBD (cannabidiol), which is found in CBD supplements, oil and topicals.

Found throughout your body, your cannabinoid receptors play an important role in your immune system, glucose metabolism, insulin resistance and blood formation. Cannabinoid receptors also control your cognition, memory, anxiety and mood, as well as your motor behavior, sensory, autonomic and neuroendocrine responses. They are responsible for inflammation’s effect on your body, and vomiting, nausea, hunger and appetite control (4).

Does the Human Body Produce Cannabinoids?

Yes. In fact, a recent study showed that the “runners high” experienced by athletes isn’t caused by endorphins—it’s caused by endocannabinoids produced naturally inside the human body. All mammals produce endocannabinoids that bind to cannabinoid receptors. The endocannabinoids reduce sensations of pain and reduce anxiety, which is one of the reasons athletes find CBD supplements reduce soreness and inflammation (2). Your body produces two types of endocannabinoids: anandamide and 2-AG. Anandamide attaches to your CB1 receptor, while 2-AG latches to CB2 receptor cells.

Endocannabinoid Deficiency

Endocannabinoid receptors are the most abundant neurotransmitter receptors in the brain. Researchers are now learning that the endocannabinoid system can become depleted, which may be associated with conditions such as migraines, fibromyalgia, irritable bowel syndrome. These conditions may be alleviated by clinical cannabis. If your body cannot make enough endocannabinoids, your mood, appetite, sleep and immune system do not function at their best. Dr. Ethan Russo recently proposed to call this Clinical Endocannabinoid Deficiency Syndrome (CEDS) (5).

Endocannabinoid System & CBD Oil

Your CB2 receptors tackle inflammation in your body and are especially attuned to receive CBD. You can replenish your endocannabinoids with supplemental CBD in the form of oil, capsules and/or topicals. CBD acts as a homeostatic regulator, meaning it helps to keep your body in balance. If you experience chronic pain and inflammation, anxiety or migraines, healing the endocannabinoid system may be the first step to feeling healthy again.

What is CBD Oil?

CBD oil is a concentrated form of CBD derived from full spectrum hemp. CBD-rich hemp is low in THC, meaning that it won’t make you feel “high” or have any psychoactive effects. You can buy CBD online in the form of tinctures, oils, capsules and topical products. CBD capsules provide a measured dosage, and CBD topicals provide relief to sore muscles. Our CBD isolate is 99.9% cannabidiol that can be added to retail formulations.

Why Buy CBD from Tree of Life Botanicals?

The process for creating our full spectrum CBD Oil begins with organically grown, CBD rich hemp plants grown in Colorado, USA. Our strains are carefully selected to contain a high amount of CBD and a very low amount of THC. Once we harvest the plants, they are processed into CBD oil, CBD capsules and CBD isolate in our extract laboratory.

References

  1. Teague, Christopher. Why Are Endocannabinoid Receptors Important? Herb. Feb. 22, 2016. Web 1. Accessed July 2017. http://herb.co/2016/02/22/why-are-cannabinoid-receptors-so-important/
  2. Orphanides, K.G. What is ‘runner’s’ high’? Study finds your body makes its own ‘cannabis’ during exercise. Wired. April 20, 2017. Web 1. July 2017. http://www.wired.co.uk/article/your-body-makes-its-own-cannabis-when-you-run
  3. https://kalytera.co/dr-raphael-mechoulam/
  4. Callen, Lucia; Barroso-Chinea, Pedro; Moreno-Delgado, David; Cortes, Antoni; Mallol, Josefa; Casado, Vicet; Lanciego, Jose Luis; Franco, Rafael; Lluis, Carmen; Canela, Enric I; McCormack, Peter J. Cannabinod Receptors CB1 and CB2 Form Functional Heteromers in Brain. The Journal of Biological Chemistry Vol. 287, No. 25, pp. 2085. JBC Papers in Press, April 24, 2012. USA. http://www.jbc.org/content/287/25/20851.full
  5. Smith, SC & Wagner, MS. Clinical Endocannabinoid Deficiency Syndrome Revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuroendocrinology Letters. https://www.ncbi.nlm.nih.gov/pubmed/24977967
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